Do I need to consider the margins of error (MOE) when comparing American Community Survey (ACS) estimates?

It is very important to consider the margins of error (MOE). This is why the American Community Survey (ACS) publishes them as a part of most data tables. Every statement in Census Bureau reports, press releases, and research papers is tested for statistical significance. Learn more about the margin of error and variance estimation in chapter 12 of the Design and Methodology Report. More information on margins of error is available in the handbook Understanding and Using American Community Survey Data: What All Data Users Need to Know.