This paper is a theoretical and empirical investigation of the connection between science, R&D, and the growth of capital. Studies of high technology industries and recent labor studies agree in assigning a large role to science and technology in the growth of human and physical capital, although direct tests of these relationships have not been carried out. This paper builds on the search approach to R&D of Evenson and Kislev (1976) to unravel the complex interactions between science, R&D, and factor markets suggested by these studies. In our theory lagged science increases the returns to R&D, so that scientific advance later feeds into growth of R&D. In turn, product quality improvements and price declines lead to the growth of industry by shifting out new product demand, perhaps at the expense of traditional industries. All this tends to be in favor of the human and physical capital used intensively by high technology industries. This is the source of the factor bias which is implicit in the growth of capital per head. Our empirical work overwhelmingly supports the contention that growth of labor skills and physical capital are linked to science and R&D. It also supports the strong sequencing of events that is a crucial feature of our model, first from science to R&D, and later to output and factor markets.